Regulation of mucin expression: Mechanistic aspects and implications for cancer and inflammatory diseases

被引:226
作者
Andrianifahanana, Mahefatiana [1 ]
Moniaux, Nicolas [1 ]
Batra, Surinder K. [1 ]
机构
[1] Univ Nebraska, Med Ctr, Eppley Inst Res Canc & Allied Dis, Dept Biochem & Mol Biol,Nebraska Med Ctr 985870, Omaha, NE 68198 USA
来源
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2006年 / 1765卷 / 02期
关键词
mucin; MUC; regulation; cancer; inflammation;
D O I
10.1016/j.bbcan.2006.01.002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Mucins are large multifunctional glycoproteins whose primary functions are to protect and lubricate the surfaces of epithelial tissues lining ducts and lumens within the human body. Several lines of evidence also support the involvement of mucins in more complex biological processes Such as epithelial cell renewal and differentiation, cell signaling, and cell adhesion. Recent studies have uncovered the role of select mucins in the pathogenesis of cancer, Underscoring the importance of a detailed knowledge about mucin biology. Under normal physiological conditions, the production of mucins is optimally maintained by a host of elaborate and coordinated regulatory mechanisms, thereby affording a well-defined pattern of tissue-, time-. and developmental state-specific distribution. However, mucin homeostasis may be disrupted by the action of environmental and/or intrinsic factors that affect cellular integrity. This results in an altered cell behavior that often culminates into a variety of pathological conditions. Deregulated mucin production has indeed been associated with numerous types of cancers and inflammatory disorders. It is, therefore, crucial to comprehend the underlying basis of molecular mechanisms controlling mucin production in order to design and implement adequate therapeutic strategies for combating these diseases. Herein, we discuss some physiologically relevant regulatory aspects of mucin production, with a particular emphasis oil aberrations that pertain to pathological situations. Our views of the achievements, the conceptual and technical limitations. as well as the future challenges associated with studies of mucin regulation are exposed. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码:189 / 222
页数:34
相关论文
共 411 条
[31]   DNA methylation patterns and epigenetic memory [J].
Bird, A .
GENES & DEVELOPMENT, 2002, 16 (01) :6-21
[32]   EXPRESSION OF MUC2-MUCIN IN COLORECTAL ADENOMAS AND CARCINOMAS OF DIFFERENT HISTOLOGICAL TYPES [J].
BLANK, M ;
KLUSSMANN, E ;
KRUGERKRASAGAKES, S ;
SCHMITTGRAFF, A ;
STOLTE, M ;
BORNHOEFT, G ;
STEIN, H ;
XING, PX ;
MCKENZIE, IFC ;
VERSTIJNEN, CPHJ ;
RIECKEN, EO ;
HANSKI, C .
INTERNATIONAL JOURNAL OF CANCER, 1994, 59 (03) :301-306
[33]   Structure and chromosomal localization of the human salivary mucin gene, MUC7 [J].
Bobek, LA ;
Liu, JH ;
Sait, SNJ ;
Shows, TB ;
Bobek, YA ;
Levine, MJ .
GENOMICS, 1996, 31 (03) :277-282
[34]  
BOBEK LA, 1993, J BIOL CHEM, V268, P20563
[35]   Cellular responses to interferon-gamma [J].
Boehm, U ;
Klamp, T ;
Groot, M ;
Howard, JC .
ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 :749-795
[36]   Detection and quantification of MUC7 in submandibular, sublingual, palatine, and labial saliva by anti-peptide antiserum [J].
Bolscher, JGM ;
Groenink, J ;
van der Kwaak, JS ;
van den Keijbus, PAM ;
van't Hof, W ;
Veerman, ECI ;
Amerongen, AVN .
JOURNAL OF DENTAL RESEARCH, 1999, 78 (07) :1362-1369
[37]   THE SEA MODULE - A NEW EXTRACELLULAR DOMAIN ASSOCIATED WITH O-GLYCOSYLATION [J].
BORK, P ;
PATTHY, L .
PROTEIN SCIENCE, 1995, 4 (07) :1421-1425
[38]   THE PRODUCT OF THE HUMAN MUC1 GENE WHEN SECRETED BY MOUSE CELLS TRANSFECTED WITH THE FULL-LENGTH CDNA LACKS THE CYTOPLASMIC TAIL [J].
BOSHELL, M ;
LALANI, EN ;
PEMBERTON, L ;
BURCHELL, J ;
GENDLER, S ;
TAYLORPAPADIMITRIOU, J .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 185 (01) :1-8
[39]  
Boudny V, 2002, NEOPLASMA, V49, P349
[40]   MUC1: A multifunctional cell surface component of reproductive tissue epithelia [J].
Brayman M. ;
Thathiah A. ;
Carson D.D. .
Reproductive Biology and Endocrinology, 2 (1)