Fabrication and characterization of electrospun zein/Ag nanocomposite mats for wound dressing applications

被引：82

作者：

Dashdorj, Uyanga ^{[1
]}

Reyes, Mark Kenneth ^{[1
]}

Unnithan, Afeesh Rajan ^{[1
]}

Tiwari, Arjun Prasad ^{[1
]}

Tumurbaatar, Batgerel ^{[1
,3
]}

Park, Chan Hee ^{[1
,2
]}

Kim, Cheol Sang ^{[1
,2
]}

机构：

[1] Chonbuk Natl Univ, Dept Bionanosyst Engn, Grad Sch, Jeonju 561756, Jeonbuk, South Korea

[2] Chonbuk Natl Univ, Div Mech Design Engn, Jeonju 561756, Jeonbuk, South Korea

[3] Mongolian Univ Sci & Technol, Power Engn Sch, Ulaanbaatar, Mongolia

来源：

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2015年 / 80卷

基金：

新加坡国家研究基金会;

关键词：

Wound dressing; Zein; Silver; Nanofibers; Electrospinning; SILVER NANOPARTICLES; COMPOSITE MATS; CROSS-LINKING; IN-VITRO; CHITOSAN; FIBERS; FILMS;

D O I：

10.1016/j.ijbiomac.2015.06.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Wound dressing is a very important factor in the process of wound healing as proper wound care can accelerate the recovery of the wound. In this study, zein nanofibrous mats with fiber diameters around 350-500 nm were prepared by electrospinning and silver (Ag) nanoparticles around 20 nm were concurrently synthesized in situ into the mats. The electrospun nanofibers were characterized by Field Emission-Scanning Electron Microscopy (FE-SEM), Transmission Electron Microscopy (TEM), Fourier Transform Infrared Spectroscopy (FIR) and X-ray photoelectron spectroscopy (XPS) analysis. Cell viability and activity of fibroblasts cells in zein/Ag mats were also evaluated and results demonstrated good cytocompatibility and attachment of cells on the composite nanofibers. Also, the bactericidal activity of the fabricated mats against gram-positive Staphylococcus aureus (S. aureus) and gram-negative Escherichia coli (E. coli) was investigated via zone of inhibition test and results showed high anti-bacterial performance. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：1 / 7

页数：7

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