Potential role of nitric oxide and endothelin in the pathogenesis of glaucoma

被引：108

作者：

Haefliger, IO ^{[1
]}

Dettmann, E ^{[1
]}

Liu, R ^{[1
]}

Meyer, P ^{[1
]}

Prünte, C ^{[1
]}

Messerli, J ^{[1
]}

Flammer, J ^{[1
]}

机构：

[1] Univ Basel, Eye Clin, Lab Ocular Pharmacol & Physiol, CH-4012 Basel, Switzerland

来源：

SURVEY OF OPHTHALMOLOGY | 1999年 / 43卷

关键词：

choroid; endothelin; endothelium-derived contracting factor; endothelium-derived relaxing factor; nitric oxide; nitric oxide synthase; normal-tension glaucoma; retina; trabecular meshwork; vasospasm;

D O I：

10.1016/S0039-6257(99)00026-0

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Glaucoma is an optic nerve head neuropathy in which retinal ganglion cells are lost. A clear association exists between glaucoma and different risk factors, such as high intraocular pressure (IOP) or blood-flow dysregulation. Nitric oxide (NO) and endothelin, two recently identified cellular mediators, appear to be involved in the regulation of IOP as well as in the modulation of ocular blood flow. To some extent, NO is also involved in apoptosis, a mechanism of cell death that can lead to retinal ganglion cell loss in glaucoma. This article provides a short and simplified overview of the biochemistry of NO and endothelin and highlights the potential role of these two mediators in certain important aspects related to the pathogenesis of glaucoma. (C) 1999 by Elsevier Science Inc. All rights reserved.

引用

页码：S51 / S58

页数：8