αPIX and βPIX and their role in focal adhesion formation

被引：68

作者：

Rosenberger, G ^{[1
]}

Kutsche, K ^{[1
]}

机构：

[1] Univ Hamburg, Klinikum Eppendorf, Inst Humangenet, D-22529 Hamburg, Germany

来源：

EUROPEAN JOURNAL OF CELL BIOLOGY | 2006年 / 85卷 / 3-4期

关键词：

parvin; calpain; GIT; p95-APP; p95PKL; CAT; PAK; paxillin; integrin cluster; focal complex;

D O I：

10.1016/j.ejcb.2005.10.007

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

alpha and beta PIX belong to the group of guanine nucleotide exchange factors (GEFs) that mediate activation of members of the Rho GTPase family, in particular Rac1 and Cdc42, by stimulating the exchange of GDP for GTP. Rho family proteins are well known as regulators of the actin cytoskeleton and have been implicated in the formation of various types of focal adhesion structures. However, the function of GEF proteins during focal adhesion formation is only beginning to emerge. Here, we highlight the recent findings on a and beta PIX and their involvement in integrin-dependent signaling and suggest models for the role of PIX proteins during focal adhesion turnover. (c) 2005 Elsevier GmbH. All rights reserved.

引用

页码：265 / 274

页数：10

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