Signal transduction in keratinocytes

被引：39

作者：

Mitev, V ^{[1
]}

Miteva, L

机构：

[1] Med Univ Sofia, Dept Biochem, Fac Med, BG-1431 Sofia, Bulgaria

[2] Med Univ Sofia, Dept Dermatol, Fac Med, BG-1431 Sofia, Bulgaria

[3] Med Univ Sofia, Dept Venereol, Fac Med, BG-1431 Sofia, Bulgaria

来源：

EXPERIMENTAL DERMATOLOGY | 1999年 / 8卷 / 02期

关键词：

keratinocytes; proliferation; differentiation; protein kinases; STAT;

D O I：

10.1111/j.1600-0625.1999.tb00355.x

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Keratinocytes, a key cellular component both for homeostasis and pathophysiologic processes of the skin, secrete a number of cytokines and their proliferation and differentiation are stimulated by a variety of biological factors. The major mechanism by which cells (keratinocytes) respond to extracellular signals, is changing in protein phosphorylation. The protein phosphorylation is a consequence of the ligand/receptor binding which leads to activation of several transduction systems. In this review we emphasize on different signal transduction pathways in keratinocytes (tyrosine kinases, PKA, PKC, MAPK, casein kinase 2 etc.).

引用

页码：96 / 108

页数：13

共 83 条

[1]

Aragane Y, 1997, J INVEST DERMATOL, V108, P121

[2]

Ben-Bassat H, 1995, Exp Dermatol, V4, P82, DOI 10.1111/j.1600-0625.1995.tb00227.x

[3] EFFECTS OF THE SELECTIVE PROTEIN-KINASE-C INHIBITOR, RO-31-7549, ON THE PROLIFERATION OF CULTURED MOUSE EPIDERMAL-KERATINOCYTES [J].

BOLLAG, WB ;

DUCOTE, J ;

HARMON, CS .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1993, 100 (03) :240-246

[4]

Bollag WB, 1996, J INVEST DERMATOL, V106, P619

[5] TYROSINE PHOSPHORYLATION AS A MARKER FOR ABERRANTLY REGULATED GROWTH-PROMOTING PATHWAYS IN CELL-LINES DERIVED FROM HEAD AND NECK MALIGNANCIES [J].

CARDINALI, M ;

PIETRASZKIEWICZ, H ;

ENSLEY, JF ;

ROBBINS, KC .

INTERNATIONAL JOURNAL OF CANCER, 1995, 61 (01) :98-103

[6]

Carlomusto M, 1997, J INVEST DERMATOL, V108, P736

[7] CA2+-CALMODULIN PREVENTS MYRISTOYLATED ALANINE-RICH KINASE-C SUBSTRATE PROTEIN-PHOSPHORYLATION BY PROTEIN-KINASE CS IN C6 RAT GLIOMA-CELLS [J].

CHAKRAVARTHY, BR ;

ISAACS, RJ ;

MORLEY, P ;

WHITFIELD, JF .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (42) :24911-24916

[8] HEPATOCYTE GROWTH-FACTOR RAPIDLY INDUCES THE TYROSINE PHOSPHORYLATION OF 41-KDA AND 43-KDA PROTEINS IN MOUSE KERATINOCYTES [J].

CHATANI, Y ;

ITOH, A ;

TANAKA, E ;

HATTORI, A ;

NAKAMURA, T ;

KOHNO, M .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 185 (03) :860-866

[9] Activation of ribosomal protein S6 kinase in psoriatic lesions and cultured human keratinocytes by epidermal growth factor receptor ligands [J].

Choi, JH ;

OConnor, TP ;

Kang, S ;

Voorhees, JJ ;

Fisher, GJ .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1997, 108 (01) :98-102

[10] BRADYKININ INDUCES TYROSINE PHOSPHORYLATION OF EPIDERMAL GROWTH FACTOR-RECEPTOR AND FOCAL ADHESION PROTEINS IN HUMAN KERATINOCYTES [J].

COUTANT, KD ;

CORVAIA, N ;

RYDER, NS .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1995, 210 (03) :774-780

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