MicroRNAs: 'ribo-regulators' of glucose homeostasis

被引：105

作者：

Gauthier, BR ^{[1
]}

Wollheim, CB ^{[1
]}

机构：

[1] Univ Geneva, Med Ctr, Dept Cell Physiol & Metab, CH-1211 Geneva 4, Switzerland

来源：

NATURE MEDICINE | 2006年 / 12卷 / 01期

关键词：

D O I：

10.1038/nm0106-36

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Insulin secretion regulates glucose homeostasis and its dysregulation causes type 2 diabetes. Short noncoding microRNAs have now been shown to control exocytosis, the final event in insulin secretion. This discovery opens potential perspectives for diabetes therapy.

引用

页码：36 / 38

页数：4

共 25 条

[21] V-1, a protein expressed transiently during murine cerebellar development, regulates actin polymerization via interaction with capping protein
Taoka, M
Ichimura, T
Wakamiya-Tsuruta, A
Kubota, Y
Araki, T
Obinata, T
Isobe, T
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (08) : 5864 - 5870
[22] Control of insulin mRNA stability in rat pancreatic islets -: Regulatory role of a 3′-untranslated region pyrimidine-rich sequence
Tillmar, L
Carlsson, C
Welsh, N
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (02) : 1099 - 1106
[23] Five stages of evolving β-cell dysfunction during progression to diabetes
Weir, GC
Bonner-Weir, S
[J]. DIABETES, 2004, 53 : S16 - S21
[24] Systematic discovery of regulatory motifs in human promoters and 3′ UTRs by comparison of several mammals
Xie, XH
Lu, J
Kulbokas, EJ
Golub, TR
Mootha, V
Lindblad-Toh, K
Lander, ES
Kellis, M
[J]. NATURE, 2005, 434 (7031) : 338 - 345
[25] V-1, a catecholamine biosynthesis regulatory protein, positively controls catecholamine secretion in PC12D cells
Yamakuni, T
Yamamoto, T
Ishida, Y
Yamamoto, H
Song, SY
Adachi, E
Hiwatashi, Y
Ohizumi, Y
[J]. FEBS LETTERS, 2002, 530 (1-3) : 94 - 98

← 1 2 3 →