Genetical Genomics: Spotlight on QTL Hotspots

被引:129
作者
Breitling, Rainer [1 ]
Li, Yang [1 ]
Tesson, Bruno M. [1 ]
Fu, Jingyuan [1 ,2 ]
Wu, Chunlei [3 ]
Wiltshire, Tim [4 ]
Gerrits, Alice [5 ]
Bystrykh, Leonid V. [5 ]
de Haan, Gerald [5 ]
Su, Andrew I. [3 ]
Jansen, Ritsert C. [1 ,2 ]
机构
[1] Univ Groningen, Groningen Bioinformat Ctr, Groningen Biomol Sci & Biotechnol Inst, Haren, Netherlands
[2] Univ Groningen, Dept Human Genet, Med Ctr Groningen, Groningen, Netherlands
[3] Novartis Res Fdn, Genom Inst, San Diego, CA USA
[4] Univ N Carolina, Sch Pharm, Chapel Hill, NC USA
[5] Univ Groningen, Dept Cell Biol, Univ Med Ctr Groningen, Groningen, Netherlands
来源
PLOS GENETICS | 2008年 / 4卷 / 10期
关键词
D O I
10.1371/journal.pgen.1000232
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
引用
收藏
页数:4
相关论文
共 40 条
  • [1] Evolutionary capacitance as a general feature of complex gene networks
    Bergman, A
    Siegal, ML
    [J]. NATURE, 2003, 424 (6948) : 549 - 552
  • [2] Common and rare variants in multifactorial susceptibility to common diseases
    Bodmer, Walter
    Bonilla, Carolina
    [J]. NATURE GENETICS, 2008, 40 (06) : 695 - 701
  • [3] Genetic dissection of transcriptional regulation in budding yeast
    Brem, RB
    Yvert, G
    Clinton, R
    Kruglyak, L
    [J]. SCIENCE, 2002, 296 (5568) : 752 - 755
  • [4] Uncovering regulatory pathways that affect hematopoietic stem cell function using 'genetical genomics'
    Bystrykh, L
    Weersing, E
    Dontje, B
    Sutton, S
    Pletcher, MT
    Wiltshire, T
    Su, AI
    Vellenga, E
    Wang, JT
    Manly, KF
    Lu, L
    Chesler, EJ
    Alberts, R
    Jansen, RC
    Williams, RW
    Cooke, MP
    de Haan, G
    [J]. NATURE GENETICS, 2005, 37 (03) : 225 - 232
  • [5] Epistasis:: too often neglected in complex trait studies?
    Carlborg, Ö
    Haley, CS
    [J]. NATURE REVIEWS GENETICS, 2004, 5 (08) : 618 - U4
  • [6] Complex trait analysis of gene expression uncovers polygenic and pleiotropic networks that modulate nervous system function
    Chesler, EJ
    Lu, L
    Shou, SM
    Qu, YH
    Gu, J
    Wang, JT
    Hsu, HC
    Mountz, JD
    Baldwin, NE
    Langston, MA
    Threadgill, DW
    Manly, KF
    Williams, RW
    [J]. NATURE GENETICS, 2005, 37 (03) : 233 - 242
  • [7] Mapping determinants of human gene expression by regional and genome-wide association
    Cheung, VG
    Spielman, RS
    Ewens, KG
    Weber, TM
    Morley, M
    Burdick, JT
    [J]. NATURE, 2005, 437 (7063) : 1365 - 1369
  • [8] Naive application of permutation testing leads to inflated type I error rates
    Churchill, G. A.
    Doerge, R. W.
    [J]. GENETICS, 2008, 178 (01) : 609 - 610
  • [9] Genetical genomics in humans and model organisms
    de Koning, DJ
    Haley, CS
    [J]. TRENDS IN GENETICS, 2005, 21 (07) : 377 - 381
  • [10] Genetic regulation of gene expression during shoot development in Arabidopsis
    DeCook, R
    Lall, S
    Nettleton, D
    Howell, SH
    [J]. GENETICS, 2006, 172 (02) : 1155 - 1164