Three dimensional optical imaging of blood volume and oxygenation in the neonatal brain

被引：66

作者：

Austin, T.

Gibson, A. P.

Branco, G.

Yusof, R. Md.

Arridge, S. R.

Meek, J. H.

Wyatt, J. S.

Delpy, D. T.

Hebden, J. C.

机构：

[1] UCL, Dept Paediat & Child Hlth, London W1N 8AA, England

[2] UCL, Dept Med Phys & Bioengn, London W1N 8AA, England

[3] UCL, Dept Comp Sci, London W1N 8AA, England

来源：

NEUROIMAGE | 2006年 / 31卷 / 04期

基金：

英国惠康基金; 英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/j.neuroimage.2006.02.038

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Optical methods provide a means of monitoring cerebral oxygenation in newborn infants at risk of brain injury. A 32-channel optical imaging system has been developed with the aim of reconstructing three-dimensional images of regional blood volume and oxygenation. Full image data sets were acquired from 14 out of 24 infants studied; successful images have been reconstructed in 8 of these infants. Regional variations in cerebral blood volume and tissue oxygen saturation are present in healthy preterm infants. In an infant with a large unilateral intraventricular haemorrhage, a corresponding region of low oxygen saturation was detected. These results suggest that optical tomography may provide an appropriate technique for investigating regional cerebral haemodynamics and oxygenation at the cotside. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：1426 / 1433

页数：8

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