Metal-Free Oxidative Trifluoromethylthiolation of Terminal Alkynes with CF3SiMe3 and Elemental Sulfur

被引：231

作者：

Chen, Chao ^{[1
]}

Chu, Lingling ^{[1
]}

Qing, Feng-Ling ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China

[2] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 30期

基金：

中国国家自然科学基金;

关键词：

COPPER-CATALYZED TRIFLUOROMETHYLATION; ARYL BORONIC ACIDS; CROSS-COUPLING REACTIONS; BOND-FORMATION; REDUCTIVE ELIMINATION; FLUORINATED ETHERS; FACILE SYNTHESIS; SULFIDES; ALKENES; ARENES;

D O I：

10.1021/ja305801m

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A metal-free oxidative trifluoromethyl-thiolation of terminal alkynes using readily available CF3SiMe3 and elemental sulfur at room temperature has been developed. This reaction provides an efficient and convenient method for the preparation of alkynyl trifluoromethyl sulfides bearing a wide range of functional groups. Preliminary investigation revealed that elemental sulfur instead of air acted as the oxidant.

引用

页码：12454 / 12457

页数：4

共 81 条

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