The Cytokines Interleukin 27 and Interferon-γ Promote Distinct Treg Cell Populations Required to Limit Infection-Induced Pathology

被引：290

作者：

Hall, Aisling O'Hara ^{[1
]}

Beiting, Daniel P. ^{[2
]}

Tato, Cristina ^{[3
]}

John, Beena ^{[1
]}

Oldenhove, Guillaume ^{[5
]}

Lombana, Claudia Gonzalez ^{[1
]}

Pritchard, Gretchen Harms ^{[1
]}

Silver, Jonathan S. ^{[1
]}

Bouladoux, Nicolas ^{[5
]}

Stumhofer, Jason S. ^{[1
]}

Harris, Tajie H. ^{[1
]}

Grainger, John ^{[5
]}

Wojno, Ella D. Tait ^{[1
]}

Wagage, Sagie ^{[1
]}

Roos, David S. ^{[2
]}

Scott, Philip ^{[1
]}

Turka, Laurence A. ^{[6
]}

Cherry, Sara ^{[2
]}

Reiner, Steven L. ^{[4
]}

Cua, Daniel ^{[2
]}

Belkaid, Yasmine ^{[3
]}

Elloso, M. Merle

Hunter, Christopher A. ^{[1
]}

机构：

[1] Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA

[2] Univ Penn, Penn Genome Frontiers Inst, Dept Biol, Philadelphia, PA 19104 USA

[3] DNAX Discovery Res, Merck Res Labs, Palo Alto, CA 94304 USA

[4] Univ Penn, Dept Med, Philadelphia, PA 19104 USA

[5] NIAID, Mucosal Immunol Unit, Parasit Dis Lab, NIH, Bethesda, MD 20892 USA

[6] Harvard Univ, Beth Israel Deaconess Med Ctr, Sch Med, Transplant Inst, Boston, MA 02215 USA

来源：

IMMUNITY | 2012年 / 37卷 / 03期

关键词：

REGULATORY T-CELLS; IFN-GAMMA; EXPRESSION; BET; INDUCTION; HOMEOSTASIS; ACTIVATION; DEPLETION; RESPONSES; EFFECTOR;

D O I：

10.1016/j.immuni.2012.06.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interferon-gamma (IFN-gamma) promotes a population of T-bet(+) CXCR3(+) regulatory T (Treg) cells that limit T helper 1 (Th1) cell-mediated pathology. Our studies demonstrate that interleukin-27 (IL-27) also promoted expression of T-bet and CXCR3 in Treg cells. During infection with Toxoplasma gondii, a similar population emerged that limited T cell responses and was dependent on IFN-gamma in the periphery but on IL-27 at mucosa! sites. Transfer of Treg cells ameliorated the infection-induced pathology observed in Il27(-/-) mice, and this was dependent on their ability to produce IL-10. Microarray analysis revealed that Treg cells exposed to either IFN-gamma or IL-27 have distinct transcriptional profiles. Thus, IFN-gamma and IL-27 have different roles in Treg cell biology and IL-27 is a key cytokine that promotes the development of Treg cells specialized to control Th1 cell-mediated immunity at local sites of inflammation.

引用

页码：511 / 523

页数：13

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