A genetic link between type 2 diabetes and prostate cancer - Commentary

被引：72

作者：

Frayling, T. M. ^{[1
]}

Colhoun, H. ^{[2
]}

Florez, J. C. ^{[3
,4
]}

机构：

[1] Univ Exeter, Peninsula Coll Med & Dent, Exeter EX1 2LU, Devon, England

[2] Univ Dundee, Dundee, Scotland

[3] Massachusetts Gen Hosp, Diabet Unit, Boston, MA 02114 USA

[4] Massachusetts Gen Hosp, Ctr Human Genet Res, Boston, MA 02114 USA

来源：

DIABETOLOGIA | 2008年 / 51卷 / 10期

关键词：

epidemiology; genes; genome-wide association study; pleiotropy; prostate cancer; transcription factors; type; 2; diabetes;

D O I：

10.1007/s00125-008-1114-9

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Epidemiological studies suggest that men with type 2 diabetes are less likely than non-diabetic men to develop prostate cancer. The cause of this association is not known. Recent genetic studies have highlighted a potential genetic link between the two diseases. Two studies have identified a version (allele) of a variant in the HNF1B (also known as TCF2) gene that predisposes to type 2 diabetes, and one of them showed that the same allele protects men from prostate cancer. Other, separate, studies have identified different variants in the JAZF1 gene, one associated with type 2 diabetes, another associated with prostate cancer. These findings are unlikely to completely explain the epidemiological association between the two diseases but they provide new insight into a possible direct causal link, rather than one that is confounded or biased in some way.

引用

页码：1757 / 1760

页数：4

共 29 条

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