Genome-wide association studies provide new insights into type 2 diabetes aetiology

被引：432

作者：

Frayling, Timothy M. ^{[1
]}

机构：

[1] Univ Exeter, Peninsula Med Sch, Inst Biomed & Clin Sci, Exeter EX1 2LV, Devon, England

来源：

NATURE REVIEWS GENETICS | 2007年 / 8卷 / 09期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1038/nrg2178

中图分类号：

Q3 [遗传学];

学科分类号：

071007 [遗传学]; 090102 [作物遗传育种];

摘要：

Human geneticists are currently in the middle of a race. Thanks to a new technology in the form of 'genome-wide chips', investigators can potentially find many novel disease genes in one large experiment. Type 2 diabetes has been hot out of the blocks with six recent publications that together provide convincing evidence for six new gene regions involved in the condition. Together with candidate approaches, these studies have identified 11 confirmed genomic regions that alter the risk of type 2 diabetes in the European population. One of these regions, the fat mass and obesity associated gene (FTO), represents by far the best example of an association between common variation and fat mass in the general population.

引用

页码：657 / 662

页数：6

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