How cyclodextrins can mask their toxic effect on the blood-brain barrier

被引：12

作者：

Binkowski-Machut, C

Hapiot, F

Martin, P

Cecchelli, R

Monflier, E

机构：

[1] Univ Artois, Fac Sci Jean Perrin, CNRS, FRE 2485,Lab Physicochim Interfaces & Applicat, F-62307 Lens, France

[2] Univ Artois, Fac Sci Jean Perrin, Lab Barriere Hematoencephal, F-62307 Lens, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2006年 / 16卷 / 07期

关键词：

cyclodextrins; blood-brain barrier; toxicity; permeability; endothelial cells; in vitro model;

D O I：

10.1016/j.bmcl.2006.01.031

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The toxicity of monosubstituted n-alkyldimethylammonium-beta-cyclodextrins (DMA-C-n-CD with n = 2, 4 and 12) towards endothelial cells of an in vitro model of the blood-brain barrier (BBB) was evaluated and compared to that of the native beta-CD. DMA-C-12-CD was found to be non-toxic below 10 mM due to the self-inclusion of the alkyl chain in the CD cavity. A high percentage of passage (30%) of DMA-C-12-CD through the endothelial cells has been measured. (C) 2006 Elsevier Ltd. All rights reserved.

引用

页码：1784 / 1787

页数：4

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