Bilirubin: its role in cytoprotection against oxidative stress

被引：132

作者：

Tomaro, ML

Batlle, AMD

机构：

[1] Univ Buenos Aires, Fac Farm & Bioquim, Dept Quim Biol, RA-1113 Buenos Aires, DF, Argentina

[2] Univ Buenos Aires, Fac Ciencias Exactas & Nat, CONICET, CIPYP, Buenos Aires, DF, Argentina

来源：

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY | 2002年 / 34卷 / 03期

关键词：

heme catabolism; heme oxygenase; bilirubin; oxidative stress; anti-oxidant defenses;

D O I：

10.1016/S1357-2725(01)00130-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Bilirubin, the end product of heme catabolism in mammals, is generally regarded as a potentially cytotoxic, lipid-soluble waste product that needs to be excreted. However, in the last 10 years, in vitro and in vivo studies, have demonstrated that bilirubin exhibits potent anti-oxidant properties preventing the oxidative damage triggered by a wide range of oxidant-related stimuli. Therefore, the idea of a beneficial and physiological role for bilirubin in cytoprotection against short and long-lasting oxidant-mediated cell injury is highlighted here. (C) 2002 Elsevier Science Ltd. All rights reserved.

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页码：216 / 220

页数：5

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