A recyclable copper catalysis in modified Friedlander quinoline synthesis

被引：60

作者：

Cho, Chan Sik ^{[1
]}

Ren, Wen Xiu ^{[1
]}

Yoon, Nam Sik ^{[2
]}

机构：

[1] Kyungpook Natl Univ, Dept Appl Chem, Coll Engn, Taegu 702701, South Korea

[2] Kyungpook Natl Univ, Dept Text Syst Engn, Coll Engn, Taegu 702701, South Korea

来源：

JOURNAL OF MOLECULAR CATALYSIS A-CHEMICAL | 2009年 / 299卷 / 1-2期

关键词：

2-Aminobenzyl alcohol; Recyclable copper catalyst; MS; 4A; Quinolines; Ketones; Cyclization; POLY(ETHYLENE GLYCOL); 2-AMINOBENZYL ALCOHOL; ALPHA-ALKYLATION; OXIDATIVE CYCLIZATION; SECONDARY ALCOHOLS; SOLVENT MEDIUM; KETONES; SYSTEM; DERIVATIVES; EFFICIENT;

D O I：

10.1016/j.molcata.2008.10.024

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

2-Aminobenzyl alcohol reacts with ketones in dioxane at 100 degrees C in the presence of a catalytic amount of a copper catalyst along with KOH and MS 4A under O(2) atmosphere to afford the corresponding quinolines in good yields. The catalytic system could be recovered and reused 10 times without any loss of catalytic activity. A similar catalytic System using copper catalyst/PEG-2000 is also effective for this coupling and cyclization with a similar catalytic potential. 2-Aminobenzyl alcohol is also coupled and cyclized with secondary alcohols Under the CuCl(2)/MS 4A catalytic system to give quinolines in moderate to good yields. (c) 2008 Elsevier B.V. All rights reserved.

引用

页码：117 / 120

页数：4

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