The copper-catalyzed asymmetric allylic substitution

被引：76

作者：

Alexakis, A ^{[1
]}

Malan, C ^{[1
]}

Lea, L ^{[1
]}

Tissot-Croset, K ^{[1
]}

Polet, D ^{[1
]}

Falciola, C ^{[1
]}

机构：

[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland

来源：

CHIMIA | 2006年 / 60卷 / 03期

关键词：

asymmetry; catalysis; copper; magnesium; substitution; zinc;

D O I：

10.2533/000942906777674994

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

This mini-review discusses the rapidly growing field of asymmetric copper-catalyzed chemistry. Although the allylic substitution has been less studied than the conjugate addition, recent breakthroughs have made this methodology a very valuable synthetic tool. Thus, a primary allylic halide or phosphate reacts with Grignard or diorganozinc reagents to afford the S-N' product (or gamma-product) in high regio- and enantioselectivities. Besides the results of the authors, we present also other, different approaches to this reaction, with emphasis on the organometallic and the type of chiral ligand used.

引用

页码：124 / 130

页数：7

共 58 条

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