Very efficient phosphoramidite ligand for asymmetric iridium-catalyzed allylic alkylation

被引：138

作者：

Alexakis, A ^{[1
]}

Polet, D ^{[1
]}

机构：

[1] Univ Geneva, Dept Organ Chem, CH-1211 Geneva 4, Switzerland

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 20期

关键词：

D O I：

10.1021/ol048607y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Linear or branched allylic carbonates or acetates undergo enantioselective iridium-catalyzed allylic substitution with sodium malonate. The reaction is wide in scope and affords the branched product in high yield and with high regio- (up to >99:1) and enantioselectivity (up to 98%). Ten aromatic or aliphatic substrates were successfully tested.

引用

页码：3529 / 3532

页数：4

共 33 条

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2-H

← 1 2 3 4 →