A nematode allergen elicits protection against challenge infection under specific conditions

被引：18

作者：

Hartmann, S ^{[1
]}

Sereda, MJ ^{[1
]}

Sollwedel, A ^{[1
]}

Kalinna, B ^{[1
]}

Lucius, R ^{[1
]}

机构：

[1] Humboldt Univ, Inst Biol, Dept Mol Parasitol, D-10115 Berlin, Germany

来源：

VACCINE | 2006年 / 24卷 / 17期

关键词：

nematode; tropomyosin; allergen;

D O I：

10.1016/j.vaccine.2006.01.064

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We describe tropomyosin of the filarial nematode Acanthocheilonema viteae as an allergen and study its protective potential in the natural rodent host Meriones unguiculatits (jird). Jirds immunized with recombinant E. coli-expressed A. viteae tropomyosin emusified in alum were not protected, while immunization with recombinant A. viteae tropomyosin or with protein purified from worms together with the adjuvant STP led to reduction of adult worm burdens by 30%. Vaccination with cDNA induced protection of about 30%, while application of cDNA together with aluminium phosphate increased the protection to > 40%. Our data suggest that vaccination with tropomyosin under Th1 conditions, which are untypical for nematode infections, induces protection via an antibody independent effector mechanism. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：3581 / 3590

页数：10

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