Zolpidem reduces the sleep disturbance of jet lag

被引:47
作者
Jamieson, Andrew O. [1 ]
Zammit, Gary K. [2 ]
Rosenberg, Richard S. [3 ]
Davis, Jeffrey R. [4 ]
Walsh, James K. [5 ]
机构
[1] Sleep Med Associates Texas PA, Dallas, TX 75231 USA
[2] St Lukes Roosevelt Hosp, Sleep Disorders Inst, New York, NY USA
[3] Northwestern Univ, Evanston Hosp, Evanston, IL 60201 USA
[4] Univ Texas Med Branch Galveston, Dept Family Med, Galveston, TX USA
[5] St Lukes Hosp, Unity Sleep Med & Res Ctr, St Louis, MO USA
关键词
Jet lag; Zolpidem; Transient insomnia; Hypnotics; Circadian sleep disorder;
D O I
10.1016/S1389-9457(00)00073-3
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: To determine the degree to which zolpidem 10 mg would reduce the sleep disruption associated with rapid, eastward transatlantic travel. Background: Subsequent to rapid transmeridian travel, individuals often complain of jet lag which includes transient disturbances in sleep patterns, alertness, appetite and mood. Disturbed sleep and impaired alertness appear to be the most debilitating symptoms of jet lag. Methods: This multi-center, double-blind randomized, placebo-controlled, parallel-groups study involved 138 adult (mean age 44.9 years) experienced travelers while on their regular eastward transatlantic assignments originating in the US and crossing 5-9 time zones. Subjects were normal sleepers when not traveling and had to have traveled overseas at least twice during the last 24 months. Subjects were randomized to zolpidem 10 mg or placebo for three (optionally four) consecutive nights starting with the first nighttime sleep after travel. Sleep was assessed with daily questionnaires. Results: A total of 130 subjects completed the study. Compared to placebo, zolpidem was associated with significantly improved sleep (statistically significant differences at nights indicated) longer total sleep time (night 1), reduced number of awakenings (nights 1 and 2), and improved sleep quality (nights 1, 2 and 3). Zolpidem was not associated with improvement in sleep latency. No unexpected or serious adverse events were reported and the most common adverse event was headache in both groups (9.2 and 17.6% for placebo and zolpidem, respectively). Conclusion: In seasoned travelers, zolpidem 10 mg produced significant improvement in sleep following rapid transmeridian travel. (C) 2001 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:423 / 430
页数:8
相关论文
共 28 条
  • [1] AKERSTEDT T, 1985, ANN CLIN RES, V17, P273
  • [2] American Sleep Disorders Association, 1997, INT CLASS SLEEP DIS, P118
  • [3] CARSKADON MA, 1976, AM J PSYCHIAT, V133, P12
  • [4] MELATONIN AND JET-LAG - CONFIRMATORY RESULT USING A SIMPLIFIED PROTOCOL
    CLAUSTRAT, B
    BRUN, J
    DAVID, M
    SASSOLAS, G
    CHAZOT, G
    [J]. BIOLOGICAL PSYCHIATRY, 1992, 32 (08) : 705 - 711
  • [5] COMPERATORE CA, 1990, OCCUP MED, V5, P323
  • [6] Zolpidem in the treatment of short-term insomnia: A randomized, double-blind, placebo-controlled clinical trial
    Dockhorn, RJ
    Dockhorn, DW
    [J]. CLINICAL NEUROPHARMACOLOGY, 1996, 19 (04) : 333 - 340
  • [7] DONALDSON E, 1991, AVIAT SPACE ENVIR MD, V62, P654
  • [8] Insomnia
    Hauri, PJ
    [J]. CLINICS IN CHEST MEDICINE, 1998, 19 (01) : 157 - +
  • [9] HAUTY GT, 1966, AEROSPACE MED, V37, P1257
  • [10] EFFECT OF TIME ZONE AND GAME TIME CHANGES ON TEAM PERFORMANCE - NATIONAL-FOOTBALL-LEAGUE
    JEHUE, R
    STREET, D
    HUIZENGA, R
    [J]. MEDICINE AND SCIENCE IN SPORTS AND EXERCISE, 1993, 25 (01) : 127 - 131