Migraine and MTHFR C677T genotype in a population-based sample

被引：157

作者：

Scher, AI

Terwindt, GM

Verschuren, WMM

Kruit, MC

Blom, HJ

Kowa, H

Frants, RR

van den Maagdenberg, AMJM

van Buchem, M

Ferrari, MD

Launer, LJ

机构：

[1] Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA

[2] NIA, Lab Epidemiol Demog & Biometry, NIH, Bethesda, MD 20892 USA

[3] Leiden Univ, Med Ctr, Dept Neurol, NL-2300 RA Leiden, Netherlands

[4] Natl Inst Publ Hlth & Environm Protect, Ctr Prevenet & Hlth Serv Res, NL-3720 BA Bilthoven, Netherlands

[5] Leiden Univ, Med Ctr, Dept Radiol, NL-2300 RA Leiden, Netherlands

[6] Univ Nijmegen, Radboud Med Ctr, Ctr Mol Life Sci, Nijmegen, Netherlands

[7] Tottori Univ, Fac Med, Dept Neurol, Inst Neurol Sci, Yonago, Tottori 683, Japan

[8] Leiden Univ, Med Ctr, Dept Human Genet, NL-2300 RA Leiden, Netherlands

来源：

ANNALS OF NEUROLOGY | 2006年 / 59卷 / 02期

关键词：

D O I：

10.1002/ana.20755

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: Migraine with aura is associated with increased risk of stroke. The MTHFR C677T genotype has been associated with increased risk of migraine in selected clinical samples and with elevated homocysteine, a risk factor for stroke. We assessed the association of the MTHFR C677T variant with migraine and the mediating effect of cardiovascular risk factors and metabolic markers of genotype status. Methods: We compared adult migraineurs with aura (MA; n = 187), without aura (MO; n = 226), and nonmigraineurs (n = 1,212) from the population-based Genetic Epidemiology of Migraine study. Results: Compared with the wild-type genotype, the T/T genotype was associated with increased odds of MA (odds ratio [OR], 2.05; 95% confidence interval, 1.2-3.4; p < 0.006), with a trend of increasing numbers of T alleles (OR, 1.40; 95% confidence interval, 1.1-1.8; p < 0.007). ORs were slightly attenuated after adjusting for homocysteine. Interpretation: Risk of MA is associated with MTHFR C674T homozygosity, independent of other cardiovascular risk factors.

引用

页码：372 / 375

页数：4

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