Biochemical markers of psoriasis as a metabolic disease

被引：45

作者：

Gerkowicz, Agnieszka ^{[1
]}

Pietrzak, Aldona ^{[1
]}

Szepietowski, Jacek Cezary ^{[2
]}

Radej, Sebastian ^{[3
]}

Chodorowska, Grazyna ^{[1
]}

机构：

[1] Med Univ Lublin, Dept Dermatol Venereol & Pediat Dermatol, PL-20080 Lublin, Poland

[2] Med Univ, Dept Dermatol Venereol & Allergol, Wroclaw, Poland

[3] Med Univ Lublin, Dept Human Anat, PL-20080 Lublin, Poland

来源：

FOLIA HISTOCHEMICA ET CYTOBIOLOGICA | 2012年 / 50卷 / 02期

关键词：

psoriasis; metabolic syndrome; adipokines; cytokines; uric acid; CRP; PAI-1; NECROSIS-FACTOR-ALPHA; REGULATORY T-CELLS; PLASMINOGEN-ACTIVATOR INHIBITOR-1; C-REACTIVE PROTEIN; SERUM URIC-ACID; BODY-MASS INDEX; ENDOTHELIAL GROWTH-FACTOR; ELEVATED PLASMA-LEVELS; APOLIPOPROTEIN-A-I; INSULIN-RESISTANCE;

D O I：

10.5603/FHC.2012.0025

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Psoriasis is a chronic immune mediated inflammatory skin disease with a population prevalence of 2-3%. In recent years, psoriasis has been recognized as a systemic disease associated with metabolic syndrome or its components such as: obesity, insulin resistance, hypertension and atherogenic dyslipidemia. Many bioactive substances have appeared to be related to metabolic syndrome. Based on current literature, we here discuss the possible role of adiponectin, leptin, ghrelin, resistin, inflammatory cytokines, plasminogen activator inhibitor 1, uric acid, C-reactive protein and lipid abnormalities in psoriasis and in metabolic syndrome. (Folia Histochemica et Cytobiologica 2012, Vol. 50, No. 2, 155-170)

引用

页码：155 / 170

页数：16

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