Transcriptional control of B-cell development

被引：119

作者：

Schebesta, M ^{[1
]}

Heavey, B ^{[1
]}

Busslinger, M ^{[1
]}

机构：

[1] Vienna Bioctr, Res Inst Mol Pathol, A-1030 Vienna, Austria

来源：

CURRENT OPINION IN IMMUNOLOGY | 2002年 / 14卷 / 02期

关键词：

D O I：

10.1016/S0952-7915(02)00324-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Significant progress has recently been made in our understanding of how transcription factors such as PU.1, Notch1, E2A, EBF, Pax5, Bcl6, Blimp1 and XBP1 control different developmental decisions during the onset and terminal phase of B-lymphopoiesis. One emerging theme is that negative regulatory networks play an important role in suppressing alternative gene programs and their corresponding cell fates throughout B-cell development.

引用

页码：216 / 223

页数：8

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