Bifunctional 2-naphthyl propargylic sulfones exhibiting high DNA intercalating and alkylating activity

被引：10

作者：

Dai, WM ^{[1
]}

Chow, CW

Zhou, L

Ishii, A

Lau, CW

Li, Q

Hamaguchi, W

Nishimoto, S

机构：

[1] Hong Kong Univ Sci & Technol, Dept Chem, Hong Kong, Peoples R China

[2] Kyoto Univ, Grad Sch Engn, Dept Energy & Hydrocarbon Chem, Kyoto 6068501, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 19期

关键词：

DNA; antitumour compds; substituent effects;

D O I：

10.1016/S0960-894X(99)00475-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A number of novel 2-naphthyl propargylic sulfones were synthesized as nucleic base alkylating agents. Extremely high DNA cleavage activity was observed for the sulfones with a free omega-hydroxyl group in the carbon chain in contrast to the ester conjugates possessing an additional intercalating unit. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2789 / 2794

页数：6

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