SYNTHESIS OF A DNA-CLEAVING BIS(PROPARGYLIC) SULFONE CROWN-ETHER

被引：44

作者：

KERWIN, SM

机构：

[1] Division of Medicinal Chemistry, College of Pharmacy, The University of Texas, Austin

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 07期

关键词：

D O I：

10.1016/S0040-4039(00)79955-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The prototypical bis(propargylic) sulfone crown ether 5 was synthesized in six steps and 26 % overall yield from readily available starting materials. In alkaline aqueous buffer, compound 5 cleaves supercoiled DNA.

引用

页码：1023 / 1026

页数：4

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