The synthesis of a coumarin analogue of retinal

被引：11

作者：

Ivanova, DI ^{[1
]}

Eremin, SV ^{[1
]}

Shvets, VI ^{[1
]}

机构：

[1] MOSCOW ACAD FINE CHEM TECHNOL MV LOMONOSOV,MOSCOW 117571,RUSSIA

来源：

TETRAHEDRON | 1996年 / 52卷 / 28期

关键词：

D O I：

10.1016/0040-4020(96)00495-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new coumarin analogue of retinal was synthesised by Wittig condensation of (2-oxo-2H-chromen-3-yl)methyltriphenylphosphonium chloride and (2E,6Z) 2,6-dimethyl-8-triphenylsilyloxyocta-2,6-dien-4-yn-1-al in high yield. Subsequent triphenylsilyl group removal, MnO2 oxidation, followed by hydrogenation over Lindlar catalyst and isomerization in the presence of traces of iodine furnished the desired polyenal. This ail-trans coumarin analogue of retinal was used for study of the bacteriorhodopsin chromophore binding site. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：9581 / 9588

页数：8

共 24 条

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