A Longitudinal 6-Year Study of the Molecular Epidemiology of Clinical Campylobacter Isolates in Oxfordshire, United Kingdom

被引：69

作者：

Cody, Alison J. ^{[1
]}

McCarthy, Noel M. ^{[1
]}

Wimalarathna, Helen L. ^{[1
]}

Colles, Frances M. ^{[1
]}

Clark, Lorraine ^{[2
]}

Bowler, Ian C. J. W. ^{[2
]}

Maiden, Martin C. J. ^{[1
]}

Dingle, Kate E. ^{[3
,4
]}

机构：

[1] Univ Oxford, Dept Zool, Oxford OX1 3PS, England

[2] Oxford Univ Hosp NHS Trust, John Radcliffe Hosp, Dept Microbiol, Oxford, England

[3] Univ Oxford, John Radcliffe Hosp, Nuffield Dept Clin Lab, Oxford OX3 9DU, England

[4] John Radcliffe Hosp, Oxford Biomed Res Ctr, Natl Inst Hlth Res, Oxford OX3 9DU, England

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2012年 / 50卷 / 10期

基金：

英国惠康基金;

关键词：

MULTILOCUS SEQUENCE TYPES; ANTIMICROBIAL RESISTANCE; ANTIBIOTIC-RESISTANCE; GENETIC DIVERSITY; TYPING SYSTEM; NEW-ZEALAND; JEJUNI; POULTRY; COLI; INFECTION;

D O I：

10.1128/JCM.01086-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Temporal and seasonal trends in Campylobacter genotypes causing human gastroenteritis were investigated in a 6-year study of 3,300 recent isolates from Oxfordshire, United Kingdom. Genotypes (sequence types [ST]) were defined using multilocus sequence typing and assigned to a clonal complex (a cluster of related strains that share four or more identical alleles with a previously defined central genotype). A previously undescribed clonal complex (ST-464) was identified which, together with ST-42, ST-45, and ST-52 complexes, showed increasing incidence. Concurrently, the incidence of ST-574, ST-607, and ST-658 complexes declined. The relative frequencies of three clonal complexes (ST-45, ST-283, and ST-42) peaked during summer and those of two (ST-353 and ST-403) peaked during winter. Nine clonal complexes (ST-22, ST-45, ST-48, ST-61, ST-257, ST-283, ST-403, ST-658, and ST-677) were significantly associated with ciprofloxacin sensitivity (P < 0.05). Seven clonal complexes (ST-49, ST-206, ST-354, ST-446, ST-460, ST-464, and ST-607) were associated with ciprofloxacin resistance (P < 0.05). Clonal complexes exhibited changing incidence and differences in seasonality and antibiotic resistance phenotype. These data also demonstrated that detailed surveillance at a single site captures information which reflects that observed nationally.

引用

页码：3193 / 3201

页数：9

共 52 条

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