Immunological hyperresponsiveness in HTLV-1 LTR-env-pX transgenic rats: A prototype animal model for collagen vascular and HTLV-I-related inflammatory diseases

被引：23

作者：

Nakamaru, Y ^{[1
]}

Ishizu, A ^{[1
]}

Ikeda, H ^{[1
]}

Sugaya, T ^{[1
]}

Fugo, K ^{[1
]}

Higuchi, M ^{[1
]}

Yamazaki, H ^{[1
]}

Yoshiki, T ^{[1
]}

机构：

[1] Hokkaido Univ, Grad Sch Med, Dept Pathol Pathophysiol, Div Pathophysiol Sci,Kita Ku, Sapporo, Hokkaido 0608638, Japan

来源：

PATHOBIOLOGY | 2001年 / 69卷 / 01期

关键词：

HTLV-1; transgenic rat; collagen vascular disease; animal model;

D O I：

10.1159/000048752

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We have earlier reported that diverse collagen vascular diseases, including arthritis, arteritis, thrombosis, myocarditis, myositis, sialo-/dacryoadenitis and dermatitis develop with the advent of autoantibodies in transgenic rats carrying the LTR-env-pX gene of human T lymphocyte virus type I (LTR-env-pX rats). To clarify the pathogenesis of these collagen vascular diseases, immunological features of LTR-env-pX rats were examined. In LTR-env-pX rats affected with these diseases, expression of CD80/86 on both tissue-infiltrating and peripheral T cells increased, compared with findings in non-transgenic rats with experimental inflammatory diseases. CD80/86 was also upregulated on peripheral T cells in LTR-env-pX rats prior to the development of diseases. Lymphocytes from LTR-env-pX rats showed an increase in autologous proliferation and were hyperreactive against several mitogens, including concanavalin A, immobilized anti-CD3 antibodies, and superantigens in vitro. Anti gen-specific immune response was also enhanced in LTR-env-pX rats. The collective evidence indicates that lymphocytes of LTR-env-pX rats constitutively express surface molecules related to T cell activation and are immunologically hyperresponsive. Bone marrow cell transfer from LTR-env-pX rats to lethally irradiated non-transgenic rats revealed that these immunologically pre-activated and hyperresponsive lymphocytes play a critical role in the pathogenesis of several collagen vascular diseases, especially of dermatitis in LTR-env-pX rats. Copyright (C) 2001 S. Karger AG, Basel.

引用

页码：11 / 18

页数：8

共 45 条

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