Co-evolution of a primordial peptide-presentation system and cellular immunity

被引：27

作者：

Boehm, T ^{[1
]}

机构：

[1] Max Planck Inst Immunobiol, Dept Dev Immunol, D-79108 Freiburg, Germany

来源：

NATURE REVIEWS IMMUNOLOGY | 2006年 / 6卷 / 01期

关键词：

D O I：

10.1038/nri1749

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

How did early vertebrates survive when their lymphocytes began to use antigen receptors with random specificities, despite their potential for extensive self-reactivity? Here, I propose that the quality-control mechanisms that tame self-reactivity in the adaptive immune system were derived, at least in part, from an ancient mechanism that guided sexual selection on the basis of evaluating genetic relatedness.

引用

页码：79 / 84

页数：6

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