Cu-catalyzed asymmetric conjugate additions of alkylzinc reagents to acyclic aliphatic enones

被引：175

作者：

Mizutani, H ^{[1
]}

Degrado, SJ ^{[1
]}

Hoveyda, AH ^{[1
]}

机构：

[1] Boston Coll, Merkert Chem Ctr, Dept Chem, Chestnut Hill, MA 02467 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2002年 / 124卷 / 05期

关键词：

D O I：

10.1021/ja0122849

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cu-catalyzed enantioselective conjugate additions to acyclic aliphatic enones are reported. The resulting enolates may be functionalized intra- and intermolecularly, leading to the formation of an additional C-C bond. The utility of the present method is not limited to reactions involving Et2Zn; a variety of alkylzincs may be used. Moreover, many of the requisite substrates can be easily accessed through catalytic olefin cross metathesis. Copyright © 2002 American Chemical Society.

引用

页码：779 / 781

页数：3

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