Asymmetric conjugate addition of diethyl zinc to enones with chiral phosphine ligands

被引：52

作者：

Alexakis, A ^{[1
]}

Burton, J ^{[1
]}

Vastra, J ^{[1
]}

Mangeney, P ^{[1
]}

机构：

[1] Univ Paris 06, URA 473 CNRS, Lab Chim Organoelements, F-75252 Paris 05, France

来源：

TETRAHEDRON-ASYMMETRY | 1997年 / 8卷 / 24期

关键词：

D O I：

10.1016/S0957-4166(97)00523-5

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Chiral bidentate aryl- and alkyl phosphines (0.5%) coordinated to copper(II) triflate (0.5%) are efficient catalysts for the asymmetric conjugate addition of diethyl zinc to cyclohexen-2-one, chalcone and benzalacetone. Among the chiral phosphines tested, (S)-Norphos, (S,S)-Chiraphos and (R)-Prophos gave the best enantiomeric excesses (44%, 44% and 36% respectively). (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

页码：3987 / 3990

页数：4

共 21 条

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