WF14861, a new cathepsins B and L inhibitor produced by Colletotrichum sp -: II.: Biological properties

被引：16

作者：

Otsuka, T ^{[1
]}

Muramatsu, Y ^{[1
]}

Niikura, K ^{[1
]}

Okamoto, M ^{[1
]}

Hino, M ^{[1
]}

Hashimoto, S ^{[1
]}

机构：

[1] Fujisawa Pharmaceut Co Ltd, Exploratory Res Labs, Tsukuba, Ibaraki 3002698, Japan

来源：

JOURNAL OF ANTIBIOTICS | 1999年 / 52卷 / 06期

关键词：

D O I：

10.7164/antibiotics.52.542

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

WF14861, 3-(N-(1-(N-(4-aminobutyl)-N-(3-aminopropyl)carbamoyl)-2-(4-hydroxy phenyl)ethyl)carbamoyl)oxirane-2-carboxylic acid, was obtained from the culture mycelium of Colletotrichum sp. as a novel cathepsins B and L inhibitor. WF14861 also showed inhibitory activities against bone derived crude protease and other cysteine proteases irt vitro. The compound ameliorated the tissue damage and the bone destruction models of low-calcium-diet-fed mouse and adjuvant arthritis rat model.

引用

页码：542 / 547

页数：6

共 10 条

[1] PEPTIDYL FLUOROMETHYL KETONES AS INHIBITORS OF CATHEPSIN-B - IMPLICATION FOR TREATMENT OF RHEUMATOID-ARTHRITIS [J].

AHMED, NK ;

MARTIN, LA ;

WATTS, LM ;

PALMER, J ;

THORNBURG, L ;

PRIOR, J ;

ESSER, RE .

BIOCHEMICAL PHARMACOLOGY, 1992, 44 (06) :1201-1207

[2]

Aibe K, 1996, BIOL PHARM BULL, V19, P1026

[3] INVIVO AND INVITRO EVIDENCE FOR THE INVOLVEMENT OF CYSTEINE PROTEINASES IN BONE-RESORPTION [J].

DELAISSE, JM ;

EECKHOUT, Y ;

VAES, G .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1984, 125 (02) :441-447

[4]

ESSER RE, 1993, J RHEUMATOL, V20, P1176

[5]

FLIPO RM, 1993, ARTHRITIS RHEUM, V36, pS252

[6] EPOXYSUCCINYL DIPEPTIDES AS SELECTIVE INHIBITORS OF CATHEPSIN-B [J].

GOURSALIN, BJ ;

LACHANCE, P ;

PLOUFFE, C ;

STORER, AC ;

MENARD, R .

JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (06) :720-725

[7]

MACIEWICZ RA, 1991, BIOMED BIOCHIM ACTA, V50, P561

[8] WF14861, a new cathepsins B and L inhibitor produced by Colletotrichum sp -: I.: Taxonomy, production, purification and structure elucidation [J].

Otsuka, T ;

Muramatsu, Y ;

Higaki, T ;

Nakanishi, T ;

Takase, S ;

Hatanaka, H ;

Okamoto, M ;

Hino, M ;

Hashimoto, S .

JOURNAL OF ANTIBIOTICS, 1999, 52 (06) :536-541

[9] NOVEL EPOXYSUCCINYL PEPTIDES - A SELECTIVE INHIBITOR OF CATHEPSIN-B, INVIVO [J].

TOWATARI, T ;

NIKAWA, T ;

MURATA, M ;

YOKOO, C ;

TAMAI, M ;

HANADA, K ;

KATUNUMA, N .

FEBS LETTERS, 1991, 280 (02) :311-315

[10]

Yamamoto N, 1996, J RHEUMATOL, V23, P1778

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