WF14861, a new cathepsins B and L inhibitor produced by Colletotrichum sp -: I.: Taxonomy, production, purification and structure elucidation

被引：7

作者：

Otsuka, T ^{[1
]}

Muramatsu, Y ^{[1
]}

Higaki, T ^{[1
]}

Nakanishi, T ^{[1
]}

Takase, S ^{[1
]}

Hatanaka, H ^{[1
]}

Okamoto, M ^{[1
]}

Hino, M ^{[1
]}

Hashimoto, S ^{[1
]}

机构：

[1] Fujisawa Pharmaceut Co Ltd, Exploratory Res Labs, Ibaraki, Osaka 3002698, Japan

来源：

JOURNAL OF ANTIBIOTICS | 1999年 / 52卷 / 06期

关键词：

D O I：

10.7164/antibiotics.52.536

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

WF14861, a novel cathepsins B and L inhibitor, was obtained from the culture mycelium of a fungus strain Colletotrichum sp. No. 14861. Spectroscopic analysis showed that WF14861 consisted of trans-epoxysuccinic acid, L-tyrosine and spermidine. WF14861 inhibited cathepsins B and L selectively.

引用

页码：536 / 541

页数：6

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