TMC-52A to D, novel cysteine proteinase inhibitors, produced by Gliocladium sp.

被引：11

作者：

Isshiki, K ^{[1
]}

Nishio, M ^{[1
]}

Sakurai, N ^{[1
]}

Uchida, T ^{[1
]}

Okuda, T ^{[1
]}

Komatsubara, S ^{[1
]}

机构：

[1] Tanabe Seiyaku Co Ltd, Lead Generat Res Lab, Toda, Saitama 3358505, Japan

来源：

JOURNAL OF ANTIBIOTICS | 1998年 / 51卷 / 07期

关键词：

D O I：

10.7164/antibiotics.51.629

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

New cysteine proteinase inhibitors, TMC-52A, B, C, and D, were isolated from the fungal fermentation broth. On the basis of a taxonomical study, the producing strain, F-2665, was characterized as Gliocladium sp. Spectroscopic analyses and chemical degradation have shown TMC-52A to D to be epoxysuccinyl peptides. TMC-52A to D strongly inhibited cysteine proteinases, in paticular, cathepsin L with IC50 values of 13 nM, 10 nM, 10 nM, and 6 nM, respectively.

引用

页码：629 / 634

页数：6

共 9 条

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