The Th17 Pathway and Inflammatory Diseases of the Intestines, Lungs, and Skin

被引：351

作者：

Weaver, Casey T. ^{[1
]}

Elson, Charles O. ^{[2
]}

Fouser, Lynette A. ^{[3
]}

Kolls, Jay K. ^{[4
]}

机构：

[1] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA

[2] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA

[3] LA Fouser Consulting, Acton, MA 02140 USA

[4] Univ Pittsburgh, Childrens Hosp Pittsburgh, Sch Med, Pittsburgh, PA 15201 USA

来源：

ANNUAL REVIEW OF PATHOLOGY: MECHANISMS OF DISEASE, VOL 8 | 2013年 / 8卷

关键词：

Th22; cells; autoimmunity; inflammatory bowel disease; Crohn's disease; ulcerative colitis; asthma; COPD; psoriasis; atopic dermatitis; INTERLEUKIN-12/23; MONOCLONAL-ANTIBODY; OBSTRUCTIVE PULMONARY-DISEASE; PSORIASIS-VULGARIS LESIONS; COLONY-STIMULATING FACTOR; SMALL-AIRWAY OBSTRUCTION; NECROSIS-FACTOR-ALPHA; VERSUS-HOST-DISEASE; TOLL-LIKE-RECEPTORS; LONG-TERM EFFICACY; T-CELLS;

D O I：

10.1146/annurev-pathol-011110-130318

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

The recent discovery of a new CD4(+) T cell subset, Th17, has transformed our understanding of the pathogenetic basis of an increasing number of chronic immune-mediated diseases. Particularly in tissues that interface with the microbial environment-such as the intestinal and respiratory tracts and the skin-where most of the Th17 cells in the body reside, dysregulated immunity to self (or the extended self, the diverse microbiota that normally colonize these tissues) can result in chronic inflammatory disease. In this review, we focus on recent advances in the biology of the Th17 pathway and on genome-wide association studies that implicate this immune pathway in human disease involving these tissues.

引用

页码：477 / 512

页数：36

共 213 条

[1] Interleukin-23 Drives Intestinal Inflammation through Direct Activity on T Cells [J].

Ahern, Philip P. ;

Schiering, Chris ;

Buonocore, Sofia ;

McGeachy, Mandy J. ;

Cua, Dan J. ;

Maloy, Kevin J. ;

Powrie, Fiona .

IMMUNITY, 2010, 33 (02) :279-288

[2] TH17 Cells in Asthma and COPD [J].

Alcorn, John F. ;

Crowe, Christopher R. ;

Kolls, Jay K. .

ANNUAL REVIEW OF PHYSIOLOGY, 2010, 72 :495-516

[3] Long-term efficacy of biologics in the treatment of psoriasis: what do we really know? [J].

Alwawi, Eihab A. ;

Krulig, Eliana ;

Gordon, Kenneth B. .

DERMATOLOGIC THERAPY, 2009, 22 (05) :431-440

[4] Interleukin-22, a member of the IL-10 subfamily, induces inflammatory responses in colonic subepithelial myofibroblasts [J].

Andoh, A ;

Zhang, ZB ;

Inatomi, O ;

Fujino, S ;

Deguchi, Y ;

Araki, Y ;

Tsujikawa, T ;

Kitoh, K ;

Kim-Mitsuyama, S ;

Takayanagi, A ;

Shimizu, N ;

Fujiyama, Y .

GASTROENTEROLOGY, 2005, 129 (03) :969-984

[5] Phenotypic and functional features of human Th17 cells [J].

Annunziato, Francesco ;

Cosmi, Lorenzo ;

Santarlasci, Veronica ;

Maggi, Laura ;

Liotta, Francesco ;

Mazzinghi, Benedetta ;

Parente, Eliana ;

Fili, Lucia ;

Ferri, Simona ;

Frosali, Francesca ;

Giudici, Francesco ;

Romagnani, Paola ;

Parronchi, Paola ;

Tonelli, Francesco ;

Maggi, Enrico ;

Romagnani, Sergio .

JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (08) :1849-1861

[6] Human Th17 cells: Are they different from murine Th17 cells? [J].

Annunziato, Francesco ;

Cosmi, Lorenzo ;

Liotta, Francesco ;

Maggi, Enrico ;

Romagnani, Sergio .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2009, 39 (03) :637-640

[7] IL-22 mediates mucosal host defense against Gram-negative bacterial pneumonia [J].

Aujla, Shean J. ;

Chan, Yvonne R. ;

Zheng, Mingquan ;

Fei, Mingjian ;

Askew, David J. ;

Pociask, Derek A. ;

Reinhart, Todd A. ;

McAllister, Florencia ;

Edeal, Jennifer ;

Gaus, Kristi ;

Husain, Shahid ;

Kreindler, James L. ;

Dubin, Patricia J. ;

Pilewski, Joseph M. ;

Myerburg, Mike M. ;

Mason, Carol A. ;

Iwakura, Yoichiro ;

Kolls, Jay K. .

NATURE MEDICINE, 2008, 14 (03) :275-281

[8] The majority of epidermal T cells in Psoriasis vulgaris lesions can produce type 1 cytokines, interferon-γ, interleukin-2, and tumor necrosis factor-α, defining TC1 (cytotoxic T lymphocyte) and TH1 effector populations:: a type 1 differentiation bias is also measured in circulating blood T cells in psoriatic patients [J].

Austin, LM ;

Ozawa, M ;

Kikuchi, T ;

Walters, IB ;

Krueger, JG .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1999, 113 (05) :752-759

[9] Normal keratinocytes express Toll-like receptors (TLRs) 1, 2 and 5: modulation of TLR expression in chronic plaque psoriasis [J].

Baker, BS ;

Ovigne, JM ;

Powles, AV ;

Corcoran, S ;

Fry, L .

BRITISH JOURNAL OF DERMATOLOGY, 2003, 148 (04) :670-679

[10] Therapeutic targeting of the IL-12/23 pathways: generation and characterization of ustekinumab [J].

Benson, Jacqueline M. ;

Sachs, Clifford W. ;

Treacy, George ;

Zhou, Honghui ;

Pendley, Charles E. ;

Brodmerkel, Carrie M. ;

Shankar, Gopi ;

Mascelli, Mary A. .

NATURE BIOTECHNOLOGY, 2011, 29 (07) :615-624

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