Modulation of transcriptional activity by antioxidant carotenoids

被引:19
作者
Sharoni, Yoav [1 ,2 ]
Agbaria, Riad [2 ,3 ]
Amir, Hadar [1 ,2 ]
Ben-Dor, Anat [1 ,2 ]
Bobilev, Irene [1 ,2 ]
Doubi, Noga [1 ,2 ]
Giat, Yudit [1 ,2 ]
Hirsh, Keren [1 ,2 ]
Izumchenko, Gaby [1 ,2 ]
Khanin, Marina [1 ,2 ]
Kirilov, Elena [1 ,2 ]
Krimer, Rita [1 ,2 ]
Nahum, Amit [1 ,2 ]
Steiner, Michael [1 ,2 ]
Walfisch, Yossi [1 ,2 ]
Walfisch, Shlomo [2 ,4 ]
Zango, Gabi [1 ,2 ]
Danilenko, Michael [1 ,2 ]
Levy, Joseph [1 ,2 ]
机构
[1] Ben Gurion Univ Negev, Fac Hlth Sci, Dept Clin Biochem, IL-84105 Beer Sheva, Israel
[2] Soroka Med Ctr Kupat Holim, IL-84105 Beer Sheva, Israel
[3] Ben Gurion Univ Negev, Fac Hlth Sci, Dept Pharmacol, IL-84105 Beer Sheva, Israel
[4] Ben Gurion Univ Negev, Fac Hlth Sci, Colorectal Unit, IL-84105 Beer Sheva, Israel
基金
以色列科学基金会;
关键词
D O I
10.1016/S0098-2997(03)00033-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
It is widely accepted that diet changes are a powerful means to prevent cancer. The possible involvement of transcriptional activity in the anticancer activity of carotenoids will be the focus of this review. Carotenoids function as potent antioxidants, and this is clearly a major mechanism of their action. In addition carotenoids action involves interference in several pathways related to cancer cell proliferation and includes changes in the expression of many proteins participating in these processes such as connexins, phase II enzymes, cyclins, cyclindependent kinases and their inhibitors. These changes in protein expression suggest that the initial effect involves modulation of transcription by figand-activated nuclear receptors or by other transcription factors. It is feasible to suggest that carotenoids and their oxidized derivatives interact with a network of transcription systems that are activated by different ligands at low affinity and specificity and that this activation leads to the synergistic inhibition of cell growth. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码:371 / 384
页数:14
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