In depth analysis of the in vivo toxicity of nanoparticles of porous iron(III) metal-organic frameworks

被引：307

作者：

Baati, Tarek ^{[1
]}

Njim, Leila ^{[2
]}

Neffati, Fadoua ^{[3
]}

Kerkeni, Abdelhamid ^{[4
]}

Bouttemi, Muriel ^{[1
]}

Gref, Ruxandra ^{[5
]}

Najjar, Mohamed Fadhel ^{[3
]}

Zakhama, Abdelfateh ^{[2
]}

Couvreur, Patrick ^{[5
]}

Serre, Christian ^{[1
]}

Horcajada, Patricia ^{[1
]}

机构：

[1] Univ Versailles, Inst Lavoisier, UMR 8180, CNRS, St Quentin En Yvelines, France

[2] CHU Monastir, Serv Anat & Cytol Pathol, Monastir, Tunisia

[3] CHU Monastir, Lab Biochim & Toxicol, Monastir, Tunisia

[4] Fac Med Monastir, Unite Elements Trace & Antioxydants, Monastir, Tunisia

[5] Univ Paris, CNRS, UMR 8612, Fac Pharm, F-75252 Paris 11, France

来源：

CHEMICAL SCIENCE | 2013年 / 4卷 / 04期

关键词：

LIQUID-PHASE EXTRACTION; DRUG-DELIVERY; IRON; LIVER; RAT; ACID; NO; CYTOCHROME-P450; QUANTIFICATION; MIL-100(FE);

D O I：

10.1039/c3sc22116d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In vivo acute toxicity of high doses of nanoparticles of three different porous iron(III) carboxylate Metal-Organic Frameworks (nanoMOFs) was intravenously investigated in rats by evaluating their distribution, metabolism and excretion. All studied parameters (serum, enzymatic, histological, etc.) are in agreement with a low acute toxicity. The mechanism of degradation and excretion of the nanoMOFs has been evidenced and shows that the nanoparticles are rapidly sequestered by the liver and spleen, then further biodegraded and directly eliminated in urine or feces without metabolization and substantial toxicity.

引用

页码：1597 / 1607

页数：11

共 88 条

[1]

ADAMS DO, 1976, AM J PATHOL, V84, P164

[2] Cation-Triggered Drug Release from a Porous Zinc-Adeninate Metal-Organic Framework [J].

An, Jihyun ;

Geib, Steven J. ;

Rosi, Nathaniel L. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (24) :8376-+

[3] Symbiosis of zeolite-like metal-organic frameworks (rho-ZMOF) and hydrogels: Composites for controlled drug release [J].

Ananthoji, Ramakanth ;

Eubank, Jarrod F. ;

Nouar, Farid ;

Mouttaki, Hasnaa ;

Eddaoudi, Mohamed ;

Harmon, Julie P. .

JOURNAL OF MATERIALS CHEMISTRY, 2011, 21 (26) :9587-9594

[4]

[Anonymous], HEPATOLOGY

[5]

AUST S D, 1985, Journal of Free Radicals in Biology and Medicine, V1, P3, DOI 10.1016/0748-5514(85)90025-X

[6]

Baati T., 2011, J PHARM BIOMED ANAL, V4, P758

[7] In vitro determination of the CYP 3A4 activity in rat hepatic microsomes by liquid-phase extraction and HPLC-photodiode array detection [J].

Baati, Tarek ;

Horcajada, Patricia ;

Gref, Ruxandra ;

Couvreur, Patrick ;

Serre, Christian .

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS, 2012, 66 (01) :29-34

[8] Quantification of tetramethyl-terephthalic acid in rat liver, spleen and urine matrices by liquid-liquid phase extraction and HPLC-photodiode array detection [J].

Baati, Tarek ;

Horcajada, Patricia ;

David, Olivier ;

Gref, Ruxandra ;

Couvreur, Patrick ;

Serre, Christian .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2012, 67-68 :98-103

[9] The prolongation of the lifespan of rats by repeated oral administration of [60] fullerene [J].

Baati, Tarek ;

Bourasset, Fanchon ;

Gharbi, Najla ;

Njim, Leila ;

Abderrabba, Manef ;

Kerkeni, Abdelhamid ;

Szwarc, Henri ;

Moussa, Fathi .

BIOMATERIALS, 2012, 33 (19) :4936-4946

[10] Quantification of trimesic acid in liver, spleen and urine by high-performance liquid chromatography coupled to a photodiode-array detection [J].

Baati, Tarek ;

Horcajada, Patricia ;

Gref, Ruxandra ;

Couvreur, Patrick ;

Serre, Christian .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2011, 879 (23) :2311-2314

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