Induction of quinone reductase by withanolides

被引：53

作者：

Misico, RI

Song, LL

Veleiro, AS

Cirigliano, AM

Tettamanzi, MC

Burton, G

Bonetto, GM

Nicotra, VE

Silva, GL

Gil, RR

Oberti, JC

Kinghorn, AD ^{[1
]}

Pezzuto, JM

机构：

[1] Univ Illinois, Coll Pharm, Program Collaborat Res Pharmaceut Sci, Chicago, IL 60680 USA

[2] Univ Illinois, Coll Pharm, Dept Med Chem & Pharmacognosy, Chicago, IL 60680 USA

[3] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Organ, RA-1428 Buenos Aires, DF, Argentina

[4] Univ Nacl Cordoba, Dept Quim Organ, IMBIV CONICET, RA-5000 Cordoba, Argentina

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 05期

关键词：

D O I：

10.1021/np0106337

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Thirty-seven naturally occurring withanolides (1-37), previously isolated in our laboratories, were evaluated for their potential to induce quinone reductase with cultured murine hepatoma cells (Hepa 1c1c7). Spiranoid (29, 32) and 18-functionalized withanolides (2-5, 7-9, 24) were found to be potent inducers of the enzyme, while 5alpha-substituted derivatives exhibited weak activity. Preliminary studies were performed with compound 29 to evaluate enzyme-inducing capacity in multiple organ sites of BALB/c mice. Significant induction was observed in liver and colon, but not in lung, stomach, or mammary gland.

引用

页码：677 / 680

页数：4

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