Stereochemistry of the interaction between methionine sulfur and the protein core

被引：19

作者：

Carugo, O ^{[1
]}

机构：

[1] Univ Pavia, Dept Gen Chem, I-27100 Pavia, Italy

来源：

BIOLOGICAL CHEMISTRY | 1999年 / 380卷 / 04期

关键词：

protein data bank; protein core; protein structure; side-chain;

D O I：

10.1515/BC.1999.064

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The stereochemical features of the interaction between the sulfur atom of methionine residues and surrounding atoms are examined on a large set of known protein crystal structures. It appears that the minimum energy conformations observed in small molecule crystals are not observed within the protein core. This suggests that these interactions are either of little intensity, though they might contribute to regulate the protein physiological behavior, or physicochemically different from their counterpart in small molecule crystals.

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页码：495 / 498

页数：4

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