Phosphatidylinositol 3-phosphate recognition by the FYVE domain

被引：143

作者：

Kutateladze, TG

Ogburn, KD

Watson, WT

de Beer, T

Emr, SD

Burd, CG

Overduin, M

机构：

[1] Univ Colorado, Hlth Sci Ctr, Dept Pharmacol, Denver, CO 80262 USA

[2] Univ Penn, Sch Med, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA

[3] Univ Penn, Sch Med, Inst Human Gene Therapy, Philadelphia, PA 19104 USA

[4] Univ Calif San Diego, Howard Hughes Med Inst, Div Cellular & Mol Med, Sch Med, La Jolla, CA 92093 USA

来源：

MOLECULAR CELL | 1999年 / 3卷 / 06期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S1097-2765(01)80013-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recognition of phosphatidylinositol 3-phosphate (Ptdlns(3)P) is crucial for a broad range of cellular signaling and membrane trafficking events regulated by phosphoinositide (Pl) 3-kinases. Ptdlns(3)P binding by the FYVE domain of human early endosome autoantigen 1 (EEA1), a protein implicated in endosome fusion, involves two beta hairpins and an a helix. Specific amino acids, including those of the FYVE domain's conserved RRHHCRQCGNIF motif, contact soluble and micelle-embedded lipid and provide specificity for Ptdlns(3)P over Ptdlns(5)P and Ptdlns, as shown by heteronuclear magnetic resonance spectroscopy. Although the FYVE domain relies on a zinc-binding motif reminiscent of RING fingers, it is distinguished by novel structural features and its Ptdlns(3)P-binding site.

引用

页码：805 / 811

页数：7

共 28 条

[1] ASSOCIATION OF BIOMOLECULAR SYSTEMS VIA PULSED-FIELD GRADIENT NMR SELF-DIFFUSION MEASUREMENTS
ALTIERI, AS
HINTON, DP
BYRD, RA
[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (28) : 7566 - 7567
[2] STRUCTURE OF THE C3HC4 DOMAIN BY H-1-NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPY - A NEW STRUCTURAL CLASS OF ZINC-FINGER
BARLOW, PN
LUISI, B
MILNER, A
ELLIOTT, M
EVERETT, R
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1994, 237 (02) : 201 - 211
[3] Crystal structure of the RAG1 dimerization domain reveals multiple zinc-binding motifs including a novel zinc binuclear cluster
Bellon, SF
Rodgers, KK
Schatz, DG
Coleman, JE
Steitz, TA
[J]. NATURE STRUCTURAL BIOLOGY, 1997, 4 (07) : 586 - 591
[4] THE SOLUTION STRUCTURE OF THE RING FINGER DOMAIN FROM THE ACUTE PROMYELOCYTIC LEUKEMIA PROTO-ONCOPROTEIN PML
BORDEN, KLB
BODDY, MN
LALLY, J
OREILLY, NJ
MARTIN, S
HOWE, K
SOLOMON, E
FREEMONT, PS
[J]. EMBO JOURNAL, 1995, 14 (07) : 1532 - 1541
[5] Phospholipid-binding protein domains
Bottomley, MJ
Salim, K
Panayotou, G
[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS, 1998, 1436 (1-2): : 165 - 183
[6] Phosphatidylinositol(3)-phosphate signaling mediated by specific binding to RING FYVE domains
Burd, CG
Emr, SD
[J]. MOLECULAR CELL, 1998, 2 (01) : 157 - 162
[7] The endosome fusion regulator early-endosomal autoantigen 1 (EEA1) is a dimer
Callaghan, J
Simonsen, A
Gaullier, JM
Toh, BH
Stenmark, H
[J]. BIOCHEMICAL JOURNAL, 1999, 338 : 539 - 543
[8] The Rab5 effector EEA1 is a core component of endosome docking
Christoforidis, S
McBride, HM
Burgoyne, RD
Zerial, M
[J]. NATURE, 1999, 397 (6720) : 621 - 625
[9] DELAGLIO F, 1993, NMRPIPE SYSTEM SOFTW
[10] FYVE fingers bind Ptdins(3)P
Gaullier, JM
Simonsen, A
D'Arrigo, A
Bremnes, B
Stenmark, H
Aasland, R
[J]. NATURE, 1998, 394 (6692) : 432 - 433

← 1 2 3 →