C/EBP beta is a negative regulator of human papillomavirus type 11 in keratinocytes

被引：41

作者：

Wang, H

Liu, K

Yuan, F

Berdichevsky, L

Taichman, LB

Auborn, K

机构：

[1] ALBERT EINSTEIN COLL MED,DEPT OTOLARYNGOL,LONG ISL JEWISH MED CTR,NEW HYDE PK,NY 11040

[2] SUNY STONY BROOK,SCH DENT MED,DEPT ORAL BIOL & PATHOL,STONY BROOK,NY 11794

来源：

JOURNAL OF VIROLOGY | 1996年 / 70卷 / 07期

关键词：

D O I：

10.1128/JVI.70.7.4839-4844.1996

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have evaluated the impact of the CCAAT enhancer-binding protein (C/EBP) transcription factors on human papillomavirus type 11 (HPV11). C/EBP beta is in nuclei of cultured foreskin keratinocytes and binds its consensus sequence in HPV11 DNA. We have used the novel approach of depleting the availability of C/EBPs in vivo using nuclease-resistant oligomers containing C/EBP DNA binding sites. In cultured foreskin keratinocytes containing replicating HPV11 DNA, levels of both HPV11 transcripts and HPV DNA increase after treatment with oligomers containing the C/EBP beta DNA binding motif. These results indicate that C/EBP beta is a repressor for HPV11 in keratinocytes.

引用

页码：4839 / 4844

页数：6

共 57 条

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