The Secret Life of Smad4

被引：29

作者：

Wrana, Jeffrey L. ^{[1
,2
]}

机构：

[1] Mt Sinai Hosp, Ctr Syst Biol, Toronto, ON M5G 1X5, Canada

[2] Univ Toronto, Dept Mol Genet, Toronto, ON M5G 1X5, Canada

来源：

CELL | 2009年 / 136卷 / 01期

关键词：

SYNAPTIC GROWTH; PATHWAY;

D O I：

10.1016/j.cell.2008.12.028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Smad4 is an important mediator of signaling by TGF beta family members that is presumed to be controlled by the phosphorylation status of its partners, the receptor-regulated R-Smads. In this issue, Dupont et al. (2009) now reveal that Smad4 itself is subject to cycles of ubiquitination and deubiquitination that regulate its interactions with the R-Smads.

引用

页码：13 / 14

页数：2

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