A highly efficient strategy for the synthesis of 3-substituted salicylic acids by either directed ortho-lithiation or halogen-metal exchange of substituted MOM protected phenols followed by carboxylation.

被引：8

作者：

Lau, SYW ^{[1
]}

Keay, BA ^{[1
]}

机构：

[1] Univ Calgary, Dept Chem, Calgary, AB T2N 1N4, Canada

来源：

CANADIAN JOURNAL OF CHEMISTRY-REVUE CANADIENNE DE CHIMIE | 2001年 / 79卷 / 11期

关键词：

salicylic acids; ortho-metalation; halogen-metal exchange; methoxymethyl group;

D O I：

10.1139/cjc-79-11-1541

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly efficient synthesis of various 3-substituted salicylic acids is described starting from inexpensive starting materials and requiring no special apparatus.

引用

页码：1541 / 1545

页数：5

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