Aromatic P-1 replacements for the highly potent HIV-1 protease inhibitor CRIXIVAN(R)

被引：7

作者：

Coburn, CA

Young, MB

Hungate, RW

Isaacs, RCA

Vacca, JP

Huff, JR

机构：

[1] Department of Medicinal Chemistry, Merck Research Laboratories, West Point

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 16期

关键词：

D O I：

10.1016/0960-894X(96)00345-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of analogs of CRIXIVAN(R) containing various aromatic P-1 ligands were prepared and evaluated for inhibition of the HIV-1 protease enzyme. These new compounds were found to be effective inhibitors at nanomolar concentrations in the in vitro enzyme inhibition assay as well as the whole cell assay. Copyright (C) 1996 Elsevier Science Ltd

引用

收藏

页码：1937 / 1940

页数：4

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