NEW DIPEPTIDE ISOSTERES USEFUL FOR THE INHIBITION OF HIV-1 PROTEASE

被引：32

作者：

KALDOR, SW

HAMMOND, M

DRESSMAN, BA

FRITZ, JE

CROWELL, TA

HERMANN, RA

机构：

[1] Lilly Research Laboratories, Eli Lilly and Company, Indianapolis

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(01)80367-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A family of readily accessible Phe-Pro mimics has been devised in which ortho-substituted benzamides serve as proline surrogates. When suitably functionalized, these dipeptide isosteres afford potent inhibitors of HIV-1 protease which are also effective in whole cell antiviral assays.

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页码：1385 / 1390

页数：6

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