Vascular endothelial growth factor production is stimulated by gangliosides and TGF-beta isoforms in human glioma cells in vitro

被引：99

作者：

Koochekpour, S ^{[1
]}

Merzak, A ^{[1
]}

Pilkington, GJ ^{[1
]}

机构：

[1] INST PSYCHIAT,DEPT NEUROPATHOL,LONDON SE5 8AF,ENGLAND

来源：

CANCER LETTERS | 1996年 / 102卷 / 1-2期

关键词：

gangliosides; growth factors; vascular endothelial growth factor; glioma;

D O I：

10.1016/0304-3835(96)04161-4

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Vascular endothelial growth factor (VEGF) is an angiogenic factor which is known to be expressed in several malignancies including glioma. The effect of transforming growth factor-beta (TGF-beta) isoforms as well as gangliosides on VEGF production was investigated in human glioma cell lines. TGF-beta isoforms and gangliosides were found to differentially stimulate VEGF production by these cells. The ganglioside GD3 enhanced this release to the greatest extent and the stimulation was more marked in a glioblastoma cell line than in the two other anaplastic astrocytoma cell lines. These results suggest that both TGF-beta s and gangliosides may act as indirect angiogenic factors by stimulating VEGF secretion.

引用

页码：209 / 215

页数：7

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