Induction of protective CTL responses in newborn mice by a murine retrovirus

被引：368

作者：

Sarzotti, M

Robbins, DS

Hoffman, PM

机构：

[1] UNIV MARYLAND, SCH MED, DEPT MICROBIOL & IMMUNOL, BALTIMORE, MD 21201 USA

[2] UNIV MARYLAND, SCH MED, DEPT NEUROL, BALTIMORE, MD 21201 USA

来源：

SCIENCE | 1996年 / 271卷 / 5256期

关键词：

D O I：

10.1126/science.271.5256.1726

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The susceptibility of neonates to virus-induced disease is thought to reflect, in part, the immaturity of their immune systems. However, inoculation of newborn mice with low doses of Cas-Br-M murine leukemia virus induced a protective cytotoxic T lymphocyte (CTL) response. The inability of neonates to develop a CTL response to high doses of virus was not the result of immunological immaturity but correlated with the induction of a nonprotective type 2 cytokine response. Thus, the initial viral dose is critical in the development of protective immunity in newborns.

引用

收藏

页码：1726 / 1728

页数：3

相关论文

共 43 条

[1] HELMINTH INFECTION RESULTS IN DECREASED VIRUS-SPECIFIC CD8+ CYTOTOXIC T-CELL AND TH1-CYTOKINE RESPONSES AS WELL AS DELAYED VIRUS CLEARANCE [J].

ACTOR, JK ;

SHIRAI, M ;

KULLBERG, MC ;

BULLER, RML ;

SHER, A ;

BERZOFSKY, JA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (03) :948-952

[2]

ADKINS B, 1994, J IMMUNOL, V153, P3378

[3] ESTABLISHMENT OF STABLE, CELL-MEDIATED-IMMUNITY THAT MAKES SUSCEPTIBLE MICE RESISTANT TO LEISHMANIA-MAJOR [J].

BRETSCHER, PA ;

WEI, GJ ;

MENON, JN ;

BIELEFELDTOHMANN, H .

SCIENCE, 1992, 257 (5069) :539-542

[4] BIOLOGY OF CLONED CYTO-TOXIC LYMPHOCYTES-T SPECIFIC FOR LYMPHOCYTIC CHORIOMENINGITIS VIRUS - CLEARANCE OF VIRUS INVIVO [J].

BYRNE, JA ;

OLDSTONE, MBA .

JOURNAL OF VIROLOGY, 1984, 51 (03) :682-686

[5] ENHANCED TYPE-2 AND DIMINISHED TYPE-1 CYTOKINES IN NEONATAL TOLERANCE [J].

CHEN, NX ;

FIELD, EH .

TRANSPLANTATION, 1995, 59 (07) :933-941

[6] B-CELLS TURN OFF VIRGIN BUT NOT MEMORY T-CELLS [J].

FUCHS, EJ ;

MATZINGER, P .

SCIENCE, 1992, 258 (5085) :1156-1159

[7]

FUCHS EJ, 1996, SCIENCE, V271, P1723

[8] SPONTANEOUS LOWER MOTOR NEURON DISEASE APPARENTLY CAUSED BY INDIGENOUS TYPE-C RNA VIRUS IN WILD MICE [J].

GARDNER, MB ;

HENDERSON, BE ;

OFFICER, JE ;

RONGEY, RW ;

PARKER, JC ;

OLIVER, C ;

ESTES, JD ;

HUEBNER, RJ .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1973, 51 (04) :1243-+

[9] RECIPROCAL EXPRESSION OF INTERFERON-GAMMA OR INTERLEUKIN-4 DURING THE RESOLUTION OR PROGRESSION OF MURINE LEISHMANIASIS - EVIDENCE FOR EXPANSION OF DISTINCT HELPER T-CELL SUBSETS [J].

HEINZEL, FP ;

SADICK, MD ;

HOLADAY, BJ ;

COFFMAN, RL ;

LOCKSLEY, RM .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 169 (01) :59-72

[10] EFFECTS OF VIRAL SPECIFIC CYTOTOXIC LYMPHOCYTES ON THE EXPRESSION OF MURINE LEUKEMIA-VIRUS INDUCED NEUROLOGIC DISEASE [J].

HOFFMAN, PM ;

CIMINO, EF ;

ROBBINS, DS .

JOURNAL OF NEUROIMMUNOLOGY, 1991, 33 (02) :157-165

← 1 2 3 4 5 →