Chromatographic response functions in 1D and 2D chromatography as tools for assessing chemical complexity

被引：22

作者：

Matos, Joao T. V.

Duarte, Regina M. B. O. ^{[1
]}

Duarte, Armando C.

机构：

[1] Univ Aveiro, CESAM, P-3810193 Aveiro, Portugal

来源：

TRAC-TRENDS IN ANALYTICAL CHEMISTRY | 2013年 / 45卷

关键词：

Chemical complexity; Chemometrics; Chromatographic optimization; Chromatographic response function (CRF); Complex system; Comprehensive two-dimensional chromatography; Non-target analysis; Objective function; One-dimensional liquid chromatography (ID LC); Optimization strategy; PERFORMANCE LIQUID-CHROMATOGRAPHY; COMPREHENSIVE 2-DIMENSIONAL CHROMATOGRAPHY; OPTIMIZATION STRATEGIES APPLICATION; DERRINGERS DESIRABILITY FUNCTION; SEQUENTIAL SIMPLEX OPTIMIZATION; UNATTENDED OPTIMIZATION; OBJECTIVE FUNCTIONS; GAS-CHROMATOGRAPHY; PEAK DETECTION; SEPARATION;

D O I：

10.1016/j.trac.2012.12.013

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The design of systems for an unattended chromatographic optimization, especially the development of chromatographic response functions (CRFs), was a topic of great interest and development in the 1980s and early 1990s. This article is a critical review of the utilization of CRFs in chromatographic optimization. We discuss the most relevant CRFs, for application in 1D and 2D chromatography in accordance with the complexity of the populations and the systems from which the samples come and the type of analytical strategy. We outline the major challenges ahead for these methods in assessing chemical complexity. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：14 / 23

页数：10

共 46 条

[31] Development of a resolution metric for comprehensive two-dimensional chromatography [J].