Protection of macaques from vaginal SHIV challenge by an orally delivered CCR5 inhibitor

被引：77

作者：

Veazey, RS

Springer, MS

Marx, PA

Dufour, J

Klasse, PJ

Moore, JP

机构：

[1] Tulane Natl Primate Res Ctr, Covington, LA 70433 USA

[2] Merck Res Labs, Rahway, NJ 07065 USA

[3] Cornell Univ, Weill Med Coll, Dept Microbiol & Immunol, New York, NY 10021 USA

来源：

NATURE MEDICINE | 2005年 / 11卷 / 12期

关键词：

D O I：

10.1038/nm1321

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pre-exposure oral prophylaxis with antiviral drugs is a potential method for preventing transmission of human immunodeficiency virus type 1 (HIV-1). We show that oral delivery of CMPD167, a small molecule that binds to the CCR5 coreceptor, for 10-14 d can protect a substantial proportion of macaques from vaginal infection with a CCR5-using virus (SHIV-162P3). The macaques that became infected despite receiving CMPD167 had reduced plasma viremia levels during the earliest stages of infection.

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收藏

页码：1293 / 1294

页数：2

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