Perturbation and exploitation of host cell cytoskeleton by periodontal pathogens

被引：16

作者：

Ellen, RP ^{[1
]}

机构：

[1] Univ Toronto, Fac Dent, Toronto, ON M5G 1G6, Canada

来源：

MICROBES AND INFECTION | 1999年 / 1卷 / 08期

基金：

英国医学研究理事会;

关键词：

periodontal infections; extracellular matrix; cytoskeletal perturbation; bacterial invasion; signaling pathways;

D O I：

10.1016/S1286-4579(99)80062-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Some periodontal pathogens disrupt epithelial barriers and cellular adhesion to the extracellular matrix, which affects the cytoskeleton. Palphyromonas gingivalis and Actinobacillus actinomycetemcomitans exploit the cytoskeleton during their uptake by epithelial cells. Treponema denticola perturbs actin and actin-regulating pathways in host cells. Cytoskeletal dysfunction due to pathogenic bacteria may impair physiologic remodeling and wound repair in the periodontium. (C) Elsevier, Paris.

引用

收藏

页码：621 / 632

页数：12

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