Natural malaria infection in Anopheles gambiae is regulated by a single genomic control region

被引：201

作者：

Riehle, MM

Markianos, K

Niaré, O

Xu, JN

Li, J

Touré, AM

Podiougou, B

Oduol, F

Diawara, S

Diallo, M

Coulibaly, B

Ouatara, A

Kruglyak, L

Traoré, SF

Vernick, KD ^{[1
]}

机构：

[1] Univ Minnesota, Ctr Microbial & Plant Genom, St Paul, MN 55108 USA

[2] Univ Minnesota, Dept Microbiol, St Paul, MN 55108 USA

[3] Fred Hutchinson Canc Res Ctr, Program Computat Biol, Seattle, WA 98109 USA

[4] Univ Bamako, Dept Epidemiol Affectat Parasitaires, Bamako, Mali

[5] Princeton Univ, Carl Icahn Lab, Dept Ecol & Evolutionary Biol, Princeton, NJ 08544 USA

[6] Princeton Univ, Lewis Sigler Inst Integrat Genom, Princeton, NJ 08544 USA

来源：

SCIENCE | 2006年 / 312卷 / 5773期

关键词：

D O I：

10.1126/science.1124153

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We surveyed an Anopheles gambiae population in a West African malaria transmission zone for naturally occurring genetic loci that control mosquito infection with the human malaria parasite, Plasmodium falciparum. The strongest Plasmodium resistance loci cluster in a small region of chromosome 2L and each locus explains at least 89% of parasite-free mosquitoes in independent pedigrees. Together, the clustered loci form a genomic Plasmodium-resistance island that explains most of the genetic variation for malaria parasite infection of mosquitoes in nature. Among the candidate genes in this chromosome region, RNA interference knockdown assays confirm a role in Plasmodium resistance for Anopheles Plasmodium-responsive leucine-rich repeat 1 (APL1), encoding a leucine-rich repeat protein that is similar to molecules involved in natural pathogen resistance mechanisms in plants and mammals.

引用

页码：577 / 579

页数：3

共 16 条

[1] Leucine-rich repeats and pathogen recognition in Toll-like receptors [J].